![]() ![]() ![]() Across all treatment phases, the incidence of treatment-related adverse events of grade 3 or higher was 78.0% in the pembrolizumab–chemotherapy group and 73.0% in the placebo–chemotherapy group, including death in 0.4% (3 patients) and 0.3% (1 patient), respectively. ![]() After a median follow-up of 15.5 months (range, 2.7 to 25.0), 58 of 784 patients (7.4%) in the pembrolizumab–chemotherapy group and 46 of 390 patients (11.8%) in the placebo–chemotherapy group had disease progression that precluded definitive surgery, had local or distant recurrence or a second primary tumor, or died from any cause (hazard ratio, 0.63 95% CI, 0.43 to 0.93). ResultsĪt the first interim analysis, among the first 602 patients who underwent randomization, the percentage of patients with a pathological complete response was 64.8% (95% confidence interval, 59.9 to 69.5) in the pembrolizumab–chemotherapy group and 51.2% (95% CI, 44.1 to 58.3) in the placebo–chemotherapy group (estimated treatment difference, 13.6 percentage points 95% CI, 5.4 to 21.8 P<0.001). The primary end points were a pathological complete response at the time of definitive surgery and event-free survival in the intention-to-treat population. After definitive surgery, the patients received adjuvant pembrolizumab or placebo every 3 weeks for up to nine cycles. In this phase 3 trial, we randomly assigned (in a 2:1 ratio) patients with previously untreated stage II or stage III triple-negative breast cancer to receive neoadjuvant therapy with four cycles of pembrolizumab (at a dose of 200 mg) every 3 weeks plus paclitaxel and carboplatin (784 patients the pembrolizumab–chemotherapy group) or placebo every 3 weeks plus paclitaxel and carboplatin (390 patients the placebo–chemotherapy group) the two groups then received an additional four cycles of pembrolizumab or placebo, and both groups received doxorubicin–cyclophosphamide or epirubicin–cyclophosphamide. Whether the addition of pembrolizumab to neoadjuvant chemotherapy would significantly increase the percentage of patients with early triple-negative breast cancer who have a pathological complete response (defined as no invasive cancer in the breast and negative nodes) at definitive surgery is unclear. Previous trials showed promising antitumor activity and an acceptable safety profile associated with pembrolizumab in patients with early triple-negative breast cancer. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. ![]() The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. ![]()
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![]() With 113 rear-wheel horsepower on tap, the big Daytona’s liquidcooled 1180cc inline-Four falls well short of many literclass sportbikes in peak power, although few match its torque output. While the Triple provides enough peak power and torque to serve any sane man’s needs, the 1200 Four has an addictive midrange kick and top-end rush that only liter-plus bikes can provide-truly an intoxicating effect. Aside from the additional cylinder and 16 pounds the 1200 carries, there are no discernible differences in chassis, ergonomics or aesthetics between them, right down to the fat, low-profile Bridgestone radiais they both wear. Fact is, both bikes share much more than a passing resemblance. From 50 feet or 50 mph, trying to distinguish a Daytona 1200 from its 900cc sibling could drive you nuts. ![]() The British company’s theme of parts commonality is taken to the extreme with its pair of Daytona sportbikes. Triumph has made the most of its inline-three and fourcylinder engines, its spine-frame chassis and numerous other common bits that turn up on various models in its product line. It’s simply a case of Triumph modular madness. HAS CYCLE World lost it? Didn’t we already see this very same bright-yellow Triumph Daytona featured on the cover of the March ’95 issue, with a full road test, to boot? Nope, you didn’t. For more information on in-house dyno tuning, click here.WHAT’S THIS, YOU MUST BE THINKING. If you are local to our factory in Port Perry, Ontario, contact us about having your bike dyno tuned in-house by our Designer and Technician, Scott Cartier. This makes the setup even more specific to your unique bike.Īdd a Power Commander V (while quantities last) or Power Commander 6 and an Autotune to any Hindle Exhaust full system or slip-on order today! If you currently have a Hindle Exhaust full system or slip-on and would like to add a Power Commander V or a Power Commander 6, just give us a call and we can help you out.
![]() ![]() Even the normal ammo is bright pink and teal, further segregating GI Jane from a play game of war with the GI Joes. This can lead to a girl abstaining from the trigger to prevent loss of her “collectible” and therefore valuable ammo. By making it collectible, you’re making it have more value. Yet Hasbro feels that for girls to play, they need to have everything be pretty, including the ammo. That’s why you can buy a bag of 100 for cheap, because they’re disposable, just like any other round of ammunition. They’re going to be trampled and ruined, they’re going to be lost in the woods. If you’ve ever played with NERF guns, you know that “collectible darts” is complete bullshit. So, why does the HeartBreaker have to be pink, white and black? Because that’s what “girls want.” And girls want toys that scream “HEY IM A GIRL” and separate them from “boy toys,” Hasbro is saying. The orange cap on the tip of the barrel is a somewhat-universal sign of “toy gun.” The reason why NERF guns are bright yellow and orange is to make it painfully obvious that these are toy guns. Sometimes they release glow-in-the-dark or clear ones. They’re mostly yellow and orange, colors that don’t have a specific gender connotation to them. Hasbro said that they could have removed the heavy-handed gendered advertising with existing NERF products, but they didn’t. To me, it feels that Hasbro found a way to capitalize on two female archer characters, Merida from Disney/Pixar’s Brave and Katniss from The Hunger Games. “I think the girls we tested it with just thought it was a cool name.” The Heartbreaker bow comes with collectable darts bearing different colors and designs there’s a Rebelle app that allows girls to play collaboratively and encourages teamwork the bow’s size and ergonomics have been tweaked so that girls as young as 6 can activate it easily.īut what about that name, “Heartbreaker” - which seems to inject an element of romance that wouldn’t be there if the bow were designed for boys, or even made to be gender neutral? “I think sometimes maybe adults are more concerned with these things than girls are,” Frascotti said. Trying to encourage girls to buy existing Nerf toys or easing up the gendered overtones of those products was never really on the table: “This is an entirely ground-up effort.” ![]() The article mentions that they did a lot of research to made this. ![]() Aspiring Princess Meridas and Katniss Everdeens can own the first Rebelle product - called the Heartbreaker bow - this fall. The line, called Nerf Rebelle, will feature projectiles that have the same power as the top items in the brand’s Nerf Elite line - but come wrapped in a prettier package and designed to encourage the collaborative play Hasbro has found girls prefer. Hasbro is hoping to hit a bullseye with its next high-profile launch - a new brand of Nerf toys aimed specifically at girls. Now, Hasbro is going to release a subline of the NERF guns known as NERF Rebelle. With the brony fandom, the lines have really blurred. The lines have blurred as time goes on, of course. MLP, Monster High and Easy Bake is for girls NERF, action figures and Star Wars is for boys. So Hasbro is guilty of selling gendered toys like any other toy company. So I’m writing it “then” and not “now.” I’ll update this if new stuff comes out from the Toy Fair. I got to see this before the Toy Fair because of press privileges. ![]() ![]() ![]() Instructions: Slide the control to adjust the kaleidoscope angle.įor all available filters go to Filters Documentation. Draw three horizontal lines across the rectangle, splitting it into three 1 14 inch (3.2 cm) pieces and one 14 inch (0.6 cm) piece. ![]() To create a kaleidoscope with Konva, we can use the įilter and set the kaleidoscopePower and kaleidoscopeAngle properties. 1 Draw an eight-by-four inch rectangle on a clear plastic report cover.This is going to be the base of your Kaleidoscope. Then apply filter with filters() function. To apply filter to an Konva.Image, we have to cache it first with cache()įunction. Getting Started Intro Overview Need help? Support Konva Tools Shapes Rect Circle Ellipse Wedge Line - Simple Line Line - Polygon Line - Spline Line - Blob Sprite Image Text TextPath Star Ring Arc Label Path RegularPolygon Arrow Custom Guides Position vs Offset Tainted Canvas Issue Styling Fill Stroke Opacity Shadow Line Join Hide and Show Mouse Cursor Style Blend Mode Fill Stroke Order Events Binding Events Mobile Events Pointer Events Desktop and Mobile Event Mobile Scrolling Multi Event Remove Event Remove by Name Listen for Events Cancel Propagation Event Delegation Fire Events Stage Events Custom Hit Region Image Hit Region Keyboard Events Desktop and Mobile Drag and Drop Drag and Drop Drag an Image Drag a Group Drag a Line Drag a Stage Drag Events Simple Drag Bounds Complex Drag and Drop Drop Events Select and Transform Basic demo Centered Scaling Keep Ratio Styling Transform Events Resize Limits Rotation Snaps Resize Snaps Stop Transform Force Update Text Resizing Ignore Stroke Clipping Simple Clip Complex Clip Groups, Layers and Ordering Groups Layering Change Containers zIndex Filters Blur Brighten Contrast Emboss Enhance Grayscale HSL HSV RGB Invert Kaleidoscope Mask Noise Pixelate Custom Filter Multiple Filters Tweens Linear Easing Common Easings All Easings Finish Event All Controls Tween Filter Complex Tweening Animations Create an Animation Moving Rotation Scaling Stop Animation Selectors Select by id Select by Type Select by Name Data & Serialization & Export Serialize a Stage Simple Load Complex Load JSON Best Practices Stage Data URL Export to HD Image Performance All tips Layer Management Batch Draw Shape Caching Optimize Animation Optimize Strokes Shape Redraw Disable Perfect Drawing Listening False Avoid Memory Leaks ![]() ![]() ![]() ![]() Certified Mail - Certified Mail provides access to online delivery information, you can be sure your article arrives at its destination.ĭon’t lose it! It’s the only official record available. When you use Certified Mail, you receive a receipt stamped with the date of mailing. A unique article number allows you to verify delivery online. As an additional security feature, the recipient's signature is obtained at the time of delivery and a record is maintained by the Post Office. For an additional fee you can add a Return Receipt or Restricted Delivery. This service cannot be used with international mail. Insured Mail - If you're sending valuable merchandise through the mail, you'll want to protect it against loss, damage or theft. You can add insurance to cover your mailing up to $5,000. You only need to insure your package for the value of its contents, as you're only covered for the actual value of the contents. For items of greater value requiring additional insurance up to $25,000, use Registered Mail. Insured Mail can be used with all package services. Registered Mail - When you're sending valuable or irreplaceable items through the mail, protect them with Registered Mail. Items you send with Registered Mail are placed under tight security from the point of mailing to the point of delivery, and are insured up to $25,000 against loss or damage. You can verify the date and time of delivery and the delivery attempts online. Registered Mail can be used with First Class and Priority Mail Services. For an additional fee, you can add a Return Receipt or Restricted Delivery. USPS Tracking - You can verify when your package was delivered or get information on delivery attempts, forwardings, or returns. USPS Tracking is now available to most APO/FPO destinations and some Pacific Islands. USPS Tracking can be used with First Class Mail Parcels, Priority Mail, Standard Post and Media. USPS Tracking is free with Priority Mail, Express Mail, or Standard Post. 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You could even understand the program of the entire transit ahead in the event of employing an experienced shipper. ![]() You’re able to take advantage of the mail forwarding service suppliers who guarantee the secure delivery of these goods in time. It would just not do to get your mailing list jeopardized with a less than commendable firm. Read information below to find about USPS Certified Mail, Mail Forwarding Tips and Postal News. Track USPS Certified Mail Customer Support:-Ĭontact Phone Number: 1-80 Receipt Tracking Number Format: 9407 3000 0000 0000 0000 00 About USPS Certified Mail:. ![]() ![]() ![]() Combining automatic sewing and image search color correction mart technology has the effect of “reconciliation.” Flash exports virtual hours with a simple and easy-to-use interface. Mount your photographs in 360 degrees, convert them as Flash virtual tours and connect to them.įinally, build hundreds or thousands of gigapixel pictures by exporting to Flash in a virtual tour. Based on the Autopano Pro program and integrating its features, Autopano Giga goes much beyond panorama creation. Kolor Autopano Giga Pro 4 Crack is software that allows you to create gigapixel photos, virtual tours, and panoramas.
![]() ![]() Toolchain Features ¶ĬMake provides the try_compile() command and wrapper macros such asĬheckCXXSourceCompiles, CheckCXXSymbolExists andĬheckIncludeFile to test capability and availability of various With the LINKER_LANGUAGE target property. Target, and in the case of static libraries, This is determined by the LANGUAGE property of source files of the Will be added to the compile command when compiling a file of a particularĬMake needs a way to determine which compiler to use to invoke the linker. The variables and the configuration-specific equivalents contain flags that ![]() The compiler identifier used by CMake CMAKE_COMPILER_VERSION The full path to the compiler used for CMAKE_COMPILER_ID Several variables relate to the language components of a toolchain which are The ENABLED_LANGUAGES global property contains the languages whichĪre currently enabled. The target architecture and bitwidth, the location of corresponding utilities When a language is enabled, CMake finds a compiler for that language, andĭetermines some information, such as the vendor and version of the compiler, With information about compiler and utility paths. In cross-compiling scenarios, a toolchain file may be specified In normal builds, CMake automaticallyĭetermines the toolchain for host builds based on system introspection andĭefaults. The toolchain utilities availableĪre determined by the languages enabled. Set(CMAKE_CXX_FLAGS_INIT "-coverage -fno-exceptions -g")Įnhanced safety checks.Cross Compiling for the Cray Linux EnvironmentĬross Compiling for Windows 10 Universal ApplicationsĬross Compiling for Android with a Standalone ToolchainĬross Compiling for Android with NVIDIA Nsight Tegra Visual Studio EditionĬross Compiling for iOS, tvOS, or watchOSĬMake uses a toolchain of utilities to compile, link libraries and createĪrchives, and other tasks to drive the build. set(CMAKE_CXX_FLAGS_INIT "-Werror -Wall -Wextra -Wpedantic") Hardened diagnostics for your unit tests. Toolchain files make cross-compilation easier, but they have other uses: When you want to generate a build system with this toolchain, specify the CMAKE_TOOLCHAIN_FILE parameter on the command line: mkdir android-arm-build & cd android-arm-buildĬmake -DCMAKE_TOOLCHAIN_FILE=$(pwd)/./arm-linux-androideadi-gcc.cmake. (You can find an example Linux cross-compiling toolchain file here.) arm-linux-androideadi-gcc.cmake with global toolchain settings: set(CMAKE_CXX_COMPILER arm-linux-gnueabihf-g++) ![]() GCC on GNU/Linux or MSVC on Windows) without any additional flags.Ĭreate a file, e.g. And your program should build for the native platform with the default toolchain (e.g. Ideally, there should be no compiler/linker flags in your CMakeLists.txt files - even within if/ endif blocks. ![]() details of how certain toolchains should be configured - separated into CMake script files, extensible by future users of your project, scalable.instructions on how to organise source files into targets - expressed in CMakeLists.txt files, entirely toolchain-agnostic and.This ensures that there is a clean division between: The preferred way to specify toolchain-specific options is using CMake's toolchain facility. The easiest one (not clean, but easy and convenient, and works only for compile flags, C & C++ at once): add_definitions($ ) Suppose you want to add those flags (better to declare them in a constant): SET(GCC_COVERAGE_COMPILE_FLAGS "-fprofile-arcs -ftest-coverage") Note: Given CMake evolution since this was answer was written in 2012, most of the suggestions here are now outdated/deprecated and have better alternatives. ![]() ![]() ![]() File Name:col0008. Rich, colorful layouts in a huge variety of themes. These have been our most popular since starting back in 1998 and now available free to the public. Apple Mail iOS Mail (the default email browser on iOS). Note: The toolbar item DOES work with dark mode but the Stationery Panel does not. Download over 1000 free web page templates for personal & commercial use. Adding a custom font to an email template allows you to use your brands fonts in email. Stationery means colorful, predesigned mail templates that you make your own by dragging in photos from your own collection. Other email programs dont have this feature, so you use other programs to send. Right Click on the Toolbar and select Customize Toolbarĭrag the icon labeled Show Stationery to your toolbar and hit doneĬlick the Show Stationery button in your toolbar Stationery Pack works with the stationery feature built-in to Apple Mail. From the developer: Mail Stationary Smart. The software lies within Communication Tools, more precisely E-mail. This Mac application is an intellectual property of Jumsoft. Open the Mail application and compose a new email Mail Stationery Smart 2.0 for Mac can be downloaded from our website for free. Simply go to the template folder where you stored you template (EMail Templates that we created in Step 1). Go to Finder>Go To Folder> /Library/Application Support/Apple/Ĭopy the Mail folder from the copied files to this folder Replace the ComposeWindow.toolbar with the ComposeWindow.toolbar from the copied files 1) Click the Compose button to create a new email. Right click on the new Mail Application and go to /Contents/Resources/ First, open your Mail app and navigate to the mailbox you want to send the message from, if you have more than one. ![]() If you would like the stationery in the original mail application then skip step 1, disable SIP, and continue with the original application, SIP can be reenabled after. Applications/Mail/Contents/Resources/ComposeWindow.toolbar But, before starting, it is recommended to download the IncrediMail Migrator. You must have a copy of the following files from a computer running High Sierra (10.13) or lower In this example I used files from Sierra (10.12) The first Stationery Pack is for Mac users who want to create sophisticated emails Stationery Pack 2 is for users with high standards in email design and technology plus there are theme-specific. ![]() ![]() ![]() The good: Even today, Chrome/Chromium is considered pretty fast. Linux users only considered it worth trying at the time due to the fact that Chrome/Chromium was perceived by many as being the fastest browser. Unlike Firefox, Chrome/Chromium was late to the game for Linux. In these posts, developers are told what has changed and what needs to be done to keep things working smoothly.Ĭhrome/Chromium – Google promotes its browser named Chrome, however I tend to put Chromium into the same group as Chrome since Chromium is used as its base for development. In fairness, Mozilla does post a blog post with each browser update for extension developers. To be blunt, this caused me to rethink which browser would be my default tool to browse the Internet. This meant I needed to verify that my favorite extensions were compatible with new Firefox updates BEFORE I updated my browser. The bad: Not too long ago, I was finding that Firefox’s frequent updates were breaking my extensions. Firefox is also great for web developers, thanks to its element inspection tool, built right into the browser. Therefore, most users feel more comfortable allowing Firefox to see their daily browsing activities whereas other browsers, might have more profit-driven interests. ![]() In addition to a straight forward privacy policy, they’re not in the “same business” as Google. Nearly every website on the Web (including government and banking sites) render properly.Īlso important: Firefox respects your privacy. Thousands of extensions to choose from to make your Firefox browser more fully featured. The good: It’s easily installed from most common Linux software repositories, if not already installed on the distro by default. It’s a fast loading, easy to navigate Web browser that has found itself in a popular place with Linux users. Accessible on both 32bit and 64bit Linux installs, Firefox also offers extensive extensions to choose from. In this article, I’ll serve as your guide through these murky waters to help you discover the best in Linux browsers.įirefox – Firefox has long been a friendly browser for Linux users. Revelations from new functionality, to broken extensions, and so forth. With this evolution, both good and bad revelations have been discovered. Choosing the best Linux browser for your needs requires just a bit of homework: Web browsers for the Linux desktop have evolved over the years, just as they have for other popular desktop platforms. ![]() ![]() Part 30 of Playlist: Songs I'd Be Disrespectfully Railed To Once that's done, though, they can get as kinky as they want. It's hard to know your partners are having kinky sex and not be interested, but BDSM isn't something you should just fall into without some proper negotiation and making sure everyone knows what they're getting into.
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